No surprises here, bed bugs love to hang out around matress seams. That's a nice quiet protected place during the day, and keeps them within easy shot of the victim's arm at night.
This photo shows another mattress seam infested with bed bugs. Notice the bed bug defication on the matress around the seam. This mostly consists of dried blood. It becomes food for bed bug larvae. The seam itself is full of shed bed bug skins.